University of Maryland, College Park, MD, USA
2021. 03. 19
A long-term, interdisciplinary research collaboration at the University of Maryland’s A. James Clark School of Engineering has made real progress in creating chemical compounds, developing new kinds of materials, and designing and building microsystems that can both detect and treat these infections.
Bacterial biofilms are almost always involved in device-associated and post-operative infections, and account for approximately half of all the estimated 700,000 to 2 million hospital infections annually. They form when planktonic bacteria adhere to moist surfaces and encase themselves in an extracellular matrix. This matrix offers significant protection for the bacteria against antimicrobial medicines, and also makes it easy for them to spread through gene transfer.
Biofilms easily form on implanted medical devices like catheters, prosthetic joints, and dental implants. Urinary catheters, some of the most commonly inserted medical devices, are susceptible to biofilm forming from bacteria in the urine at a rate of 5–7 percent per day. Because high doses of antibiotics are required for their removal, biofilms contribute to the increase in antibiotic-resistant strains of bacteria.
Doctors need far better ways to detect, measure and effectively treat biofilms.
“There is a need for non-invasive, real-time selective and sensitive detection of biofilms that can aid infectious disease practitioners in the treatment of biofilms on indwelling medical devices,” says Dr. Rodney Donlan of the Biofilm Laboratory at the Centers for Disease Control and Prevention in Atlanta.
In their 10-year collaboration, Professor Reza Ghodssi (Electrical and Computer Engineering; Institute for Systems Research), Professor William Bentley (Fischell Department of Bioengineering), and their students and colleagues have been advancing the state of the art in both biofilm detection and treatment. They have developed in-vitro microsystems that can detect and measure (“characterize”) biofilm, and in-vivo microsystems for biofilm treatment. The most recent device, which can be placed in urinary catheters, can do it all—detect, measure and treat biofilms.
자세히 보기 〉
University of Maryland, College Park, MD, USA
2021. 03. 19
A long-term, interdisciplinary research collaboration at the University of Maryland’s A. James Clark School of Engineering has made real progress in creating chemical compounds, developing new kinds of materials, and designing and building microsystems that can both detect and treat these infections.
Bacterial biofilms are almost always involved in device-associated and post-operative infections, and account for approximately half of all the estimated 700,000 to 2 million hospital infections annually. They form when planktonic bacteria adhere to moist surfaces and encase themselves in an extracellular matrix. This matrix offers significant protection for the bacteria against antimicrobial medicines, and also makes it easy for them to spread through gene transfer.
Biofilms easily form on implanted medical devices like catheters, prosthetic joints, and dental implants. Urinary catheters, some of the most commonly inserted medical devices, are susceptible to biofilm forming from bacteria in the urine at a rate of 5–7 percent per day. Because high doses of antibiotics are required for their removal, biofilms contribute to the increase in antibiotic-resistant strains of bacteria.
Doctors need far better ways to detect, measure and effectively treat biofilms.
“There is a need for non-invasive, real-time selective and sensitive detection of biofilms that can aid infectious disease practitioners in the treatment of biofilms on indwelling medical devices,” says Dr. Rodney Donlan of the Biofilm Laboratory at the Centers for Disease Control and Prevention in Atlanta.
In their 10-year collaboration, Professor Reza Ghodssi (Electrical and Computer Engineering; Institute for Systems Research), Professor William Bentley (Fischell Department of Bioengineering), and their students and colleagues have been advancing the state of the art in both biofilm detection and treatment. They have developed in-vitro microsystems that can detect and measure (“characterize”) biofilm, and in-vivo microsystems for biofilm treatment. The most recent device, which can be placed in urinary catheters, can do it all—detect, measure and treat biofilms.
자세히 보기 〉